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Many drugs which are excreted by the kidney require appropriate dose adjustment because as age progresses, there is 30-50% reduction in glomerular filtration rate along with compromised tubular function and reduced renal blood flow.

These changes ultimately cause prolongation of the drug half-life with an increase in serum drug concentration of drugs such as risperidone and amisulpride, which in turn are responsible for increased risk adverse reactions.

Keywords: Adverse drug reaction, antipsychotics, benzodiazepines, elderly, risk, zolpidem How to cite this URL: Kate NS, Pawar SS, Parkar SR, Sawant NS.

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These can have significant repercussions on the action as well as the safety of these medications.

Psychotropic drugs are commonly used to manage mental and behavioral problems in geriatric patients.

This is, however, accompanied by the risk of developing adverse drug reactions (ADRs), impacting the safety with which the drug can be used.

The number of dopaminergic receptors in the central nervous system (CNS) decreases with age.

The availability of D2 receptors in the caudate and putamen also decline with age.

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